1%) and Chronic gastritis was the
most frequent diagnosis 330 (84.6%). selleck kinase inhibitor intestinal metaplasia were uncommon and was found in only 62 patients (16%).Dysplasia with 2 cases (0.51%) was the least common. Ratio of more aggressive precancerous factors was obviously higher in patients over 35 years. Conclusion: Studied precancerous factors are common among endoscopic mucosal biopsies of Iranian patients with chronic gastritis. In comparison with current published data, frequency of the studied histopathological factors among Iranian population is related to East Asian patients and different with East European patients. Key Word(s): 1. Helicobacter; 2. Gastritis; 3. Atrophy; 4. Metaplasia; Presenting Author: YANGWEIYANGWEI YANGWEI Additional Authors: WANGNIANWANGNIAN WANGNIAN, CHENJIECHENJIE CHENJIE Corresponding Author: YANGWEIYANGWEI YANGWEI Affiliations: Union Hospital Objective: The aims of this study were to investigate the effects of synchronized gastric electrical stimulation of dual pulses(SGES) on gastric motility in different periods diabetic rats and try to explore the possible mechanisms of this method for gastric motility by observing the changes of enteric glial cell(EGC) in the stomach. Methods: Forty-six SD rats Alpelisib ic50 were used in this study. The rats were divided into three groups randomly including the
age-matched control group, diabetes group and diabetes with gastric electrical stimulation group. All rats were implanted with two pairs of gastric serosal electrodes. The diabetes group was consist of early diabetes group (1-2w) and terminal diabetes group (8-9w), the time of control group and gastric electrical stimulation group was corresponding with diabetes group. The gastric electrical stimulation group was then divided into two subgroups containing acute stimulation group (ASGES, stimulate 60 min) and chronic stimulation group (CSGES, stimulate one week continuously, 60 min/day). Gastric slow waves were recorded at baseline, the moment of established models successfully and the end immediately after electrical stimulation. Gastric emptying was assessed by using phenol red solution, the ultrastructure
of EGC in gastric antrum MCE was observed with transmission electron microscopy, and the glial marker-S100B expression was explored by immunohistochemistry and RT-PCR. Results: 1). The frequency of gastric slow waves increased and gastric emptying accelerated in early diabetes group compared with that in age-matched control group(P < 0.05), while the dysrhythmic slow waves in terminal diabetes can be observed, and gastric emptying was slower than terminal control group(P < 0.05). 2). The gastric emptying in terminal control group was slightly lower than that in early control group, but there was no significant statistical difference(P = 0.073). The frequency and rhythm were normal in both groups. 3). The S100B expression in terminal control group decreased compared to early control group(P < 0.01); 4).