2% respectively POGT failed to detect 26% of positive cases of H

2% respectively. POGT failed to detect 26% of positive cases of HBV infection, but identified 98% of those requiring vaccination. The cost of SOC was 5 times higher than POG, costing $126. 43 vs. $25. 30 per positive case. GONCLUSIONS:

Although both strips demonstrated high specificity, false negatives were frequent. The limitations of the device could be related to operator error, low HBsAg levels, assay degeneration, or other issues such as lot variation. The inaccuracy of the aniti-HBs should stimulate redesign of this test component. However, this POCT could serve as an effective screening test in high prevalence groups for HBsAg. False positives were also uncommon. This is significant for a reportable and stigmatized p38 MAPK activity disease and may lower the barriers to testing and linkage to care. Disclosures: Robert G. Gish – Advisory Committees or Review Panels: Z-IETD-FMK molecular weight Merck, Genentech, Roche, BMS, Gilead, Arrowhead; Stock Shareholder: Hepahope, Kinex, Arrowhead The following people have nothing to disclose: Julio A. Gutierrez,

Natali Navarro, Kayla Giang, David S. Adler, Binh Tran BACKGROUND and AIMS: People with alcohol related problems as consequence of short-term exposure to alcohol as well as consequences of long term alcohol use often belong to Hospital Emergency Departments. In Italy studies that consider emergency departments as the first step to recognize alcoholrelated disorders are still lacking. The aims of our study are to investigate the pattern of alcohol consumption among emergency room patients and the characteristics of alcohol consumption find more subgroup. MATERIALS and METHODS: The study was carried out at Emergency Room Department of S. Anthony

Hospital (Padua) from 8th January 2012 to 16th May 2012, 4 weeks were randomly selected. Patient solder than 18 were questioned with both AUDIT and CAGE after they had been triaged, before or after being visited. Patients who accepted to perform the tests themselves were given AUDIT and CAGE, the others were interviewed by just one interviewer. Pearson test analysis were used. RESULTS: 1520 patients were evaluated, 1000 (65. 8%) were examined and 874 (87. 4%) were interviewed. 19. 5% of interviewed patients had alcohol related problems, 30% had abuse or dependence. Higher rates were found for men (p < 0.001), young people aged 18-20 years (p < 0.028), divorced or single (p < 0.003), unemployed (p< 0.001), homeless (p = 0.005), immigrants (p < 0.001). GONCLUSIONS: Emergency Department may be the initial point of healthcare contact for patients with alcohol problems. Social outcast persons present higher risk of alcohol disorders. Screening can be useful to provide the first step of intervention in this group and is needed for early prevention and health care intervention.

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