(2012) paper The regions selected were examined bilaterally due

(2012) paper. The regions selected were examined bilaterally due to differential processing between hemispheres. Regions in our models included bilateral superior temporal gyrus (STG),

bilateral inferior frontal gyrus (IFG), bilateral premotor cortex (PMC), and bilateral primary Natural Product Library ic50 motor cortex (M1). In Parkinson 2012, superior temporal gyrus demonstrated increased activation during shift conditions when compared to no shift vocalization. Furthermore, it is involved in auditory-vocal integration and processing of predicted and actual vocal output (Zarate & Zatorre, 2005). Additionally, we investigated IFG, which was shown as an imperative part of the speech/vocalization network and has been identified as a site for additional sensory processing for motor planning and control of Ivacaftor solubility dmso vocalization (Parkinson et al., 2013, Tourville et al., 2008 and Zarate et al., 2010). Premotor cortex has been identified as a location for selecting alternatives to already programed learned responses as well as generating motor commands for speech and vocalization (Tourville et al., 2008 and Zarate

et al., 2010). Primary motor cortex was selected for its involvement in sending motor commands to be executed. Primary motor cortex is functionally connected with IFG giving rise to speech and vocalization making it an optimal candidate for this analysis (Greenlee et al., 2004). Given the limited number of data points made available by sparse sampling, subcortical regions were not included in the bilateral

model. Instead, we focused on cortical contributions to vocalization with and without shifted feedback. Separate models were created for the shift and no shift conditions. Specific coordinates for regions of interest were identified from the unshifted vocalization vs. rest contrast in a group analysis (Table 1). Individual ROIs were created (125 mm3 cubic volume centered around the specified MNI coordinate) for each of the above listed regions using the multi-image analysis GUI (Mango) image processing software (http://ric.uthscsa.edu/mango/) (Lancaster et al., 2012). Individual ROIs were converted from the normalized MNI space back to native subject space allowing Protirelin for the extraction of raw data from each individual subject while ensuring that data were extracted from the identical sites across subjects. Preprocessing was performed using the FSL 4.1.4 (FMRIB Software Library) software package. Head motion was corrected using MCFLIRT and non-brain was removed from the structural image using the BET brain extraction tool. The functional EPI images were smoothed using a FWHM of 5 mm and transformed to MNI space using FSLs registration tools. The FMRI BOLD signal was extracted from each ROI for each subject’s data set and experimental condition.

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