Monthly Archives: November 2016

First- versus second-generation medications A major focus of research over the past decade has been to establish the relative merits of first- and second-generation antipsychotics. With that, psychiatry has seen the completion of several large, government-funded trials, which attempted to … Continue reading →

We found support for our hypothesis that D-Asp activated a mixed collection of receptors by the summary actions of many reagents. D-Asp may activate at least two different known ion currents in Aplysia BSC neurons: EAATs and NMDA-like receptors selleck … Continue reading →

Drug-level manipulation can be achieved by co-administering a substance which induces or inhibits enzyme(s) responsible for the metabolism of a drug. Fluvoxamine, a potent CYP1A2 inhibitor is sometimes added to clozapine treatment as a way of boosting its plasma concentration. … Continue reading →

0 versus 2.0 days, p < 0.001; odds ratio 3.65, 95% CI 1.97- 6.75). Significant differences were noted for type of hospital intra/inter transfer category prior to EDIMCU admission (p < 0.001); however, only ICU transfer (patients that were discharged … Continue reading →

With respect to comorbidity, etiologic and prognostic studies indicate that depression may be a cause or a consequence of CVD, thus supporting a bidirectional relationship. Major depression has been identified as a prominent psychosocial risk factor in CVD incidence for … Continue reading →

Ultrasound-triggered bubble liposome destruction (sonoporation) has been proposed as a safe nonviral means of gene therapy that can target many different cells or tissues. In the field of cardiovascular medicine, this method may have significant potential for the introduction of … Continue reading →

This is to ensure that the endogenous species overlapping with the internal standard at the spectral resolution is less than 1% of the most abundant species in the class of interest. For quantification of lipid species in a biological sample, … Continue reading →

Larger and more vacuolated mitochondria were observed in axons innervating both compartments of the mutant versus WT TA (Fig. ​(Fig.10).10). The occurrence of altered mitochondria was increased in TA muscle axons, but mitochondrial pathology was also occasionally observed in the … Continue reading →

Moreover, although DTI has been instrumental in increasing understanding of the brain’s structural connectivity, its limitations as an indicator of white matter integrity must be acknowledged. DTI metrics are influenced directly and indirectly by multiple properties of white matter and … Continue reading →

With high incidences of nonadherence to medications and relapse in patients with serious mental illness, the prospect of having antipsychotics as a transdermal patch is exciting. Role of psychoeducation Achieving medication adherence and therapeutic effect using TDS requires understanding several … Continue reading →