Monthly Archives: March 2019

4B) Moreover, we did not detect a significant change in the freq

4B). Moreover, we did not detect a significant change in the frequency, absolute number or phenotype of B cells during colitis development (Supporting Information Fig. 1). While these observations do not exclude a possible role for B cells in this … Continue reading

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However, any potential changes in dialysate sodium concentration

However, any potential changes in dialysate sodium concentration can be mathematically modelled, accurately predicted and clinically compensated within the dialysis prescription such that any clinical consequences are avoided.19 Clearly, the introduction of any new technique – in any medical field … Continue reading

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It is clear that the maturation state of the DC is a crucial dete

It is clear that the maturation state of the DC is a crucial determining factor in the induction of Treg in the periphery. On one hand, by providing only partial or negative (e.g. CTLA-4) co-stimulatory signals or secreting immunosuppressive cytokines … Continue reading

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All mice studied were on the C57BL/6 background BALB/C Act1−/− m

All mice studied were on the C57BL/6 background. BALB/C.Act1−/− mice [1] were backcrossed more than 12 generations to C57Bl/6J. B6.129P-Tcrbtm1MomTcrdtm1Mom/J mice were purchased from The Jackson Laboratory (Bar Harbor, ME). Triple knockout (TKO) animals (TCRβ−/−TCRδ−/−Act1−/−) and age-matched controls (WT, Act1 … Continue reading

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Ubiquitin-positive NCIs, which are evident in the degenerating lo

Ubiquitin-positive NCIs, which are evident in the degenerating lower motor neurons, have long been recognized as a characteristic feature of the cellular pathology. However, TDP-43 immunostaining may reveal positive neuronal and glial cytoplasmic inclusions (NCIs and GCIs) not only in … Continue reading

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The γδ T-cell field has been hampered

by a lack of consen

The γδ T-cell field has been hampered by a lack of consensus with regard to nomenclature for the various γ chains. Of the two systems in common use, that of Garman [13] and that of Heilig and Tonegawa [14], we … Continue reading

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However, it is not 100% specific or sensitive due to the presence

However, it is not 100% specific or sensitive due to the presence of skip lesions. A positive biopsy is associated with a history of jaw claudication and diplopia, and temporal artery beading, prominence and tenderness on examination [18]. The European … Continue reading

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[107] Immunohistochemistry localized p65 to CEC nuclei in Pkd1−/−

[107] Immunohistochemistry localized p65 to CEC nuclei in Pkd1−/− kidney explants.[107] Similarly, Park et al. identified an unspecified phosphorylated NF-κB protein in CEC nuclei and in tubules surrounding the cysts of PKD2 mice and human ADPKD kidneys.[20] Increased levels of phosphorylated … Continue reading

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001) and 8-isoPGF2α levels (r = −0 363, n = 56, P < 0 01) On the

001) and 8-isoPGF2α levels (r = −0.363, n = 56, P 

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In recent years, adoptive transfer of Treg cells has gained major

In recent years, adoptive transfer of Treg cells has gained major attention as an alternative or complementary therapy to conventional immunosuppressive treatments with the ultimate aim of reducing the side effects of conventional drugs [12, 13]. Since only 5–10% of … Continue reading

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