Evidence-based practices to prevent catheter-related bloodstream infections have been widely promoted. One such practice includes assessing the need for central venous catheters on a daily basis and removing those found to be unnecessary. However, little is
known about the adherence to this recommendation. Our objective was to examine the prevalence of unnecessary central venous catheters in our intensive care units.\n\nMethods We performed a prospective observational study during 28 consecutive days in two adult intensive care units at an academic medical centre. The principal investigator screened patients daily for the presence of non-tunnelled central venous catheters and assessed whether there was an indication for continued central catheterization. Patients under the age of 18 were excluded, as were Adriamycin those undergoing palliative care. Standardized indications were abstracted from the patient’s chart, and the patient’s primary nurse was interviewed if there was no indication for central venous catheterization in the chart. If there were multiple catheters or indications, the CA4P most appropriate indication was recorded. The end
point was to establish whether a patient had an appropriate indication for central catheterization rather than to attribute an indication to each catheter.\n\nResults Eighty-one patients experienced a total of 614 days with at least one central venous catheter. Forty-one (50.6%; 95% confidence interval [CI], 39.9-61.3%) of these patients had no indication on at least one central venous catheter day. Of all patient days with central venous catheters, 170 (27.7%; 95% CI, 19.5-37.9%) had no apparent indication. The proportion of patient days with central venous catheters without indication was 4.6 (95% CI, 2.6-8.2; P < 0.001) times greater in the level-2 unit than in the level-3 selleck compound unit.\n\nDiscussion In two academic adult intensive care units, a large proportion of patients with central venous catheters lacked an ongoing indication for their use during
a significant period of time. Many patients were exposed to complications from unneeded catheters. Our findings will serve as a baseline for determining the success of quality-improvement interventions to prevent complications such as catheter-related infections in our program.”
“30 novel compounds have been synthesized from 25-hydroxyprotopanaxadiol (25-OH PPD) and their in vitro anti-tumor activities were tested on three cancer cell lines and one normal cell line (IOSE144) by standard MTT assay. The results showed that compound 27 exhibited the best anti-tumor activity in the in vitro assays. Compounds 1, 2, 16, 17, 18, 27, 28 and 29 have better anti-tumor activities against MCF-7 and A549 cancer cell lines than 25-OH PPD, together with low toxicity in the normal cell. The results may provide useful data for researching and developing new antitumor agents. (C) 2012 Elsevier Masson SAS. All rights reserved.