He gave his first lecture there on “Regulation of HPV Viral Oncog

He gave his first lecture there on “Regulation of HPV Viral Oncogene Expression” during which he discussed the results from the recent whole-genome siRNA screen, the pluses and minuses of the current HPV VLP vaccine, and the need for the development of specific anti-viral therapies for HPV infections and for the cancers they cause. Later, he visited the “branch of the Ludwig Institute for CDK inhibitor Cancer Research in Oxford” that is headed by Professor Xin Liu and gave a seminar

there entitled “The role of Ubiquitylation and Cancer”. It turns out that Louise and Peter have a common interest in a cellular bromodomain protein called Brd4 and were unaware of this major interface between our research interests before the visit to Oxford. Time was too short. This seems to be a common theme that is emerging yet we know that if the Visiting Professorship was for a longer duration, many people who were so offered one, would not, or could not, accept. Perhaps one possible addition to the VVP scheme would be to allow joint applications, by the VVP and their host, for six-month position for an assistant in order to further the interaction. This would give sufficient time for a full application to be made to one

of the granting authorities. Dame Louise was also the principal host of Wade Harper. He stressed PARP inhibitor trial how very rare it is for scientists to be able to spend several weeks fully away from their ongoing activities to simply Enzalutamide molecular weight learn something new and interact extensively with colleagues of orthogonal interests. The VVP provides just such an opportunity. He learned the basics of

molecular modeling, something that he would not have been able to do without the time and freedom afforded by the VVP. One forgets how busy many of one’s colleagues are. A good example is Professor Lew Cantley from the Harvard Medical School. As he wrote: “For me, the Vallee Visiting Professorship at Oxford was the closest I have come to a sabbatical experience. Being overcommitted throughout my career, finding even a single month to escape to a new academic environment was a rare and rewarding experience. Having originally trained as an enzymologist, but finding myself increasingly mired in the complexity of cancer biology, it was great fun to get back to my roots and bounce ideas about mechanisms of action of protein kinases and metabolic enzymes off my hosts and their colleagues at Oxford. Of course I did not miss the chance to impose upon my hosts to learn a bit about the rich history of Oxford University. I was accompanied by my family and I would not be surprised if my younger daughter might even have had a subliminal influence during that brief sojourn. It is a wonderful tribute to Bert and Kuggie’s vision that extremely busy people can be seduced by the convenience of the scheme to partake of the highlights it can bring.

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