Howard; (Stanford Prevention Research Center, Stanford, CA) Marci

Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (The Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/Phoenix, AZ) Cynthia A. Thomson; (University at Buffalo, Buffalo,

NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Robert Wallace; (University learn more of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker Women’s Health Initiative Memory Study: (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker For a list of all the investigators who have contributed to WHI science, please visit: https://​cleo.​whi.​org/​researchers/​Documents%20​%20​Write%20​a%20​Paper/​WHI%20​Investigator%20​Long%20​List.​pdf Funding/Support This work was partially supported by a grant from the National Osteoporosis Foundation. This sponsor was not involved in decisions concerning data analyses to be conducted, their interpretation, or in manuscript development. The WHI click here program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services

through contracts N01WH22110, 24152, 32100–2, 32105–6, 32108–9, 32111–13, 32115, 32118–32119, 32122, 42107–26, 42129–32, and 44221. Related data analytic methodology work was supported by NIH grant CA53996. Conflicts

of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Electronic Cepharanthine supplementary material Below is the link to the electronic supplementary material. Supplementary Table 1 Modeled regression variables by clinical outcome included in WHI Observational Study component of analyses. Additionally, in both the Clinical Trial and Observational Study, baseline Cox model hazard rates are stratified on cohort (CT versus OS), baseline age (5-year categories), and current use of postmenopausal estrogens and of estrogens plus progestins. Epigenetics inhibitor Additional modeled regression variables in both the CT and OS included prior use of estrogens and of estrogens plus progestins, duration of any such prior use, and FFQ estimates of usual dietary consumption of calcium and vitamin D. (DOCX 20 kb) Supplementary Figure 1 Bone mineral density averages and 95 % confidence intervals by randomization group in the WHI Calcium and Vitamin D trial: Averages are presented at baseline (Clinical Trial Year 1) and 2, 5, and 8 years later (DOCX 856 kb) References 1.

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