Inhibition of transcription elongation through the vector DNA template had no effect on the loss of VII, suggesting that transcription was not necessary for removal of the majority of protein VII. Vector DNA assembled into physiologically spaced nucleosomes within 6 h. hdAd vectors incorporated the histone H3 variant H3.3, which was dependent on the histone chaperone HIRA. Knockdown of HIRA reduced hdAd association with histones and reduced expression of the vector-carried transgene by 2- to 3-fold. Our study elucidates an essential role for hdAd DNA chromatinization for optimal vector
“Environmental dependency phenomena refer to the symptoms initially described by Lhermitte (1983, 1984) under the terms SBI-0206965 of “”utilization behavior”" and “”imitation behavior”". These clinical
signs are linked to essential notions such as free-will and human autonomy, and seem to be specific of the frontal pathology. Surprisingly, few studies have addressed these symptoms and inconsistent definitions are available. To investigate the theoretical and clinical definitions of environmental dependency phenomena, three groups of neurological patients (n = 60) with frontal, subcortical, and posterior brain lesions were compared. Clinically, our findings help to rehabilitate the definitions of Lhermitte (1983, 1984) and challenge the classical interpretation in terms of an executive control deficit. The frontal specificity of the disorders and the VE-821 nmr lack of relation between executive/behavioral deficits were supported. The right orbitofrontal cortex seems particularly involved in environmental dependency.
These results offer some evidences for differentiate two historical concepts of neuropsychology, namely the “”frontal”" and “”dysexecutive”" syndromes. A new interpretation of environmental dependency phenomena is provided which could be helpful to orient the neuropsychology of click here frontal syndrome. (C) 2011 Elsevier Ltd. All rights reserved.”
“Parkinson’s disease (PD) has been frequently associated with facial emotion recognition impairments, which could adversely affect the social functioning of those patients. Facial emotion recognition requires processing of the spatial relations between facial features, known as the facial configuration. Few studies, however, have investigated this ability in people with PD. We hypothesized that facial emotion recognition impairments in patients with PD could be accounted for by a deficit in configural processing. To assess this hypothesis, three tasks were proposed to 10 patients with PD and 10 healthy controls (HC): (i) a facial emotion recognition task with upright faces, (ii) a similar task with upside-down faces, to explore the face inversion effect, and (iii) a configural task to assess participants’ abilities to detect configural modifications made on a horizontal or vertical axis.