Mary’s Hospital, Incheon St. Mary’s Hospital, Incheon St. Mary’s Hospital, Inha University Hospital, Inha University Hospital, Soonchunhyang University Hospital, Soonchunhyang University Hospital Objective: Eradication of Helicobacter pylori infection with triple therapy (TT) has been reported to achieve unacceptable rates in Korea. The aim of this study was to compare the efficacy of sequential therapy (ST) and concomitant therapy (CT) with that of TT in Korea. Methods: For this multicentre, randomized trial,
patients with H. pylori infection from 4 centers in Korea were recruited. Patients were randomly allocated to TT (PPI, amoxicillin and clarithromycin for 10 days), ST (PPI and amoxicillin for the first 5 days, followed by PPI, clarithromycin and metronidazole for the next 5 days) or CT Sorafenib manufacturer (PPI, amoxicillin, clarithromycin and metronidazole for 10 days).
Results: From March, 2013 a total of 227 patients were enrolled in our study. Seventy nine patients were allocated to the TT, 72 patients to CT group, and 65 patients to the ST group. For ITT analysis, the eradication rates of TT, ST and CT were 59.5% (47/79), 68.1% (49/72), 80.0% (52/65), respectively. For PP analysis, the eradication rates were 79.7% (47/59), 86.0% (49/57), 96.2% (50/52), respectively. CT achieved higher eradication rates than TT and ST. The rate of adverse events and adherence to the medication was similar between the three treatment groups. Conclusion: Our prospective, multicenter study suggests that concomitant therapy may be better than triple therapy and sequential therapy for Selleck Target Selective Inhibitor Library eradication of Helicobacter pylori in Korea. More data from more patients will be followed and this should
allow us to reach more definite conclusions. Liothyronine Sodium Key Word(s): 1. triple; sequential; 2. concomitant; 3. Helicobacter pylori; 4. Korea Presenting Author: DONG SHENG LIU Additional Authors: DONGSHENG LIU, CONGHUA SONG, MENGMENG GUO, YOUHUA WANG, BEN WANG, YONG XIE, NANJIN ZHOU, NONGHUA LV Corresponding Author: YONG XIE Affiliations: First Affiliated Hospital of Nanchanguniversity, First Affiliated Hospital of Nanchanguniversity, First Affiliated Hospital of Nanchanguniversity, First Affiliated Hospital of Nanchanguniversity, First Affiliated Hospital of Nanchang University, First Affiliated Hospital of Nanchang University, Jiangxi Medical Science Institute, First Affiliated Hospital of Nanchanguniversity Objective: To monitor the resistance to metronidazole, clarithromycin, levofloxacin, tetracycline, azithromycin, rifampicin and amoxicillin of Helicobacter pylori (H. pylori) strains in Jiangxi Province. Methods: The tissue samples were collected by gastroscope biopsy from the outpatients and inpatients with gastric diseases from 2010 to 2014. 653 tissue samples cultured in microaerobic condition were identified as typical H.