Methods: A systematic review of medical records was conducted to identify patients treated with histoacryl injection for gastric varices from 1998 to 2011. Patients were graded into isolated gastric varices (IGV1 and IGV2) and gastroesophageal varices (GOV1 and GOV2). The outcome parameters included initial hemostasis, treatment failure (bleeding, need to change therapy or death within five days), rebleeding (bleeding after 5 days), complications and mortality rates. Results: Ninety-seven patients were included, mean age was 51.0 ± 12.5 years, 62% were male. Hepatitis C was the most common etiology found in 63 (65%) patients followed by www.selleckchem.com/products/rgfp966.html NonB-NonC cirrhosis
in 14 (15%), Hepatitis B in 11 (12%) and alcoholic liver disease in 5 (5%) patients. Majority of the patients were classified as Child Pugh grade B and C; 45 (46%) and 29 (30%) patients, respectively. A total of 40 (41%) patients were classified as IGV1, 35 (36%) patients as GOV2, 20 (21%) patients as GOV1 and 2 (2%) patients as IGV2. Hemostasis was achieved in 87 (90%) patients. Treatment failure occurred in 14 (15%) patients including seven patients who died during the same admission. Rebleeding was seen in 24 (27%) patients during one year follow-up out of whom 12 (50%) were successfully managed with repeated histoacryl injection. No major complications MK 1775 were observed. Mortality rate at 6 weeks,
6 months and 1 year was 8%, 13% and 21%, respectively. Conclusion: Single session of Histoacryl sclerotherapy is effective in patients with active gastric variceal bleeding. Rebleeding was observed in one fourth of patients, half of which were successfully controlled by repeated histoacryl sclerotherpy. Key Word(s): 1. Cirrhosis; 2. Histoacryl injection; 3. Gastric varices; 4. Portal hypertension; Presenting Author: HUSSEINALI OSMAN Additional Authors: HABSAH HASAN, RAPEAH SUPPIAN, NOR AIZAL CHE HAMZAH, SHARIFAH EMILIA TUAN SHARIF, NOORIZAN H A MAJID, BIN ALWI ZILFALIL Corresponding Author: HUSSEINALI OSMAN Affiliations: Universiti sains Malaysia Objective: Upper gastrointestinal
bleeding (UGIB) is a life-threatening emergency L-gulonolactone oxidase problem in the elderly population. The aim of this study is to determine the demographic characteristics, clinical features, Helicobacter pylori infection and endoscopic findings among patients aged ≥65 years admitted for UGIB compared with those aged <65 years. Methods: This is a retrospective study conducted among UGIB confirmed patients from January 2009 to December 2012 at Hospital Universiti Sains Malaysia. All those patients who are admitted at the Hospital were recruited. Data collected included age, gender, Helicobacter pylori infection, associated symptoms and Endoscopic finding. Chi- square test and Fisher’s exact test was used in Statistical Analysis. Results: There were 46 patients with a mean age of 62.37 years old. A total of 26 (56.5%) patients constituted the elderly population.