This research was supported by grants No 106734 from the Fondo d

This research was supported by grants No. 106734 from the Fondo de Investigación Básica SEP-CONACYT 2008-01 and No. 147778 from the Fondo Mixto CONACYT-Gobierno del Estado de Guerrero 2010-01. The authors declare no conflicts of interest. “
“The increasing worldwide prevalence of obesity in children and adolescents is a matter of concern, considering its association with

several comorbidities, among them cardiovascular GSK-3 assay disease.1 In addition to its association with diabetes mellitus type 2, hypertension, dyslipidemia, acute myocardial infarction and stroke,1 childhood obesity also appears to be involved in psychological and social consequences, as it may impair the self-esteem of young obese individuals and may

result in psychological consequences in the long term.2 Studies have shown an association between low quality of life and obesity in childhood and adolescence.3, 4, 5 and 6 Poor eating habits, sedentary lifestyle, and genetic predisposition are possible factors related to the development of obesity in young people. The practice of regular physical activities can prevent the onset of this condition. In addition to the benefits in the prevention and treatment of diabetes, obesity, metabolic syndrome,7 and improvement of the lipid profile,8 and 9 physical activities can also have an impact on the health-related quality of life of obese children and adolescents.10 The benefits of physical exercise and nutritional counseling on obesity are known in the young population.9 and 11 Other see more studies have shown positive effects of physical exercise with recreational activities and nutritional guidance on the components of metabolic syndrome12 and body mass index (BMI) of obese children.13 The benefits of exercise on quality of life are also highlighted; however, none of these Thiamine-diphosphate kinase studies were conducted in Brazil,3, 10, 14 and 15 and one was performed with a similar methodology as used in the present study.10 Considering the gaps, this study assessed the effects

of an intervention program with physical exercise and recreational activities combined with nutritional counseling on the health-related quality of life of obese children. This was a controlled clinical trial. The initial population of the study involved children aged between 8 and 11 years and with BMI above the 97th percentile for age and gender, according to the criteria of the World Health Organization (WHO), thus considered obese.16 The children were consecutively recruited from the Pediatric Cardiology Outpatient Clinic of the Hospital Infantil Joana de Gusmão (HIJG) of Florianópolis/SC, Brazil (a state referral center for this disease), in the period January-July 2009. The inclusion criteria were obese children between 8 and 11 years of age treated at HIJG and residents of Florianópolis/SC. The exclusion criteria were participation in any weight loss program, or physical or mental disability.

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