To our knowledge, only 3 cases were reported to achieve complete response to Sorafenib so far and our case is the longest survival recorded. Key Word(s): 1. sorafenib; 2. complete response; 3. survival; 4. advance hepatocellular carcinoma Presenting Author: RINI RACHMAWARNI BACHTIAR Additional Authors: ARI FAHRIAL SYAM, DADANG MAKMUN Corresponding Author: RINI RACHMAWARNI high throughput screening BACHTIAR Affiliations: Medical Faculty, University of Indonesia, Medical Faculty, Indonesia University
Objective: Colorectal cancer ranks as the 10th most common cancer in the world, including Indonesia. In developed countries, the incidence of colorectal cancer increases sharply after the age of 50 years; whereas only 3% are found among those patients less than 40 year of age. Data derived from Ministry of Health reveals the incidence of colorectal cancer under 45 years of age in 4 major cities of Indonesia, i.e. 47.85%, 54.5%, 44.3% and 48.2% in Jakarta, Bandung, Makassar and Padang, respectively. Compared to developed countries, there is higher incidence of young colorectal cancer patients in Indonesia. Results: We report a 36-years-old Epigenetics inhibitor female patient, who has diagnosed as tumor colon with multiple pulmonary nodule, a hepatic
nodule, multiple pericolica, mesenterial, parailiaca and inguinal lymphadenophaty and suggestive metastase in uterus and urinary bladder. She came with the complaint of diarrhea and abdominal pain since 3 months before admission. Patient had no family history of colorectal cancer or other form of malignancy. She had a disliking in fiber rich diet and had no routine regular exercise. Physical Erastin price examination revealed vital sign normal. There was increase peristaltic, rectal to use no mass and active bleeding. Laboratory findings were anemia, hypoalbuminemia and hyponatremia. The radiologic report
rectosigmoid mass infiltrating to perifatty area, uterus and vesicaurinaria. Multiple lymphadenopathy at the pericolica, mecentrical, parailiaca, and inguinal. Hepatic lesion and multiple nodule pulmonary suggestive metastase. Colonoscopy found there was mass in the rectum that almost cover the lumen and vulnerable. The histopathology result from biopsy mass in rectum was appropriate with adenocarcinoma moderate differentiation. Patient already do colostomy and decided to get chemotherapy. Conclusion: We report a real case colorectal carcinoma in young patient with multiple metastase. Key Word(s): 1. multiple metastase colorectal carcinoma in young patient Presenting Author: DEWI NORWANI BASIR Additional Authors: WEI LYN YANG Corresponding Author: DEWI NORWANI BASIR Affiliations: Tan Tock Seng Hospital Objective: Raised serum carcinoembryonic antigen (CEA) is usually associated with gastrointestinal (GI) malignancies but can be raised in non-GI malignancies. Associations with gynaecological malignancies have infrequently been reported.