CCI-779 tar- get new classes of proteins and improve the output of drug discovery

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Garber K (009) Drugging the Wnt pathway: problems and progress. J Natl Cancer Inst 0:548 – 550 35. Sierra JR, Cepero V, Giordano S (00) Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy. Mol Cancer 9:75 36. Cunningham MP, Thomas H, Marks C et al (008) Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR6 and the IGF-IR tyrosine kinase inhibitor NVP-AEW54 in colorectal cancer cells. Int J Oncol 33:07 – 3 7 M OUNT S INAI J OURNAL OF M  environments EDICINE 359 have been developed and clinically approved for the treatment of several cancers. The desire to tar- get new classes of proteins and improve the output of drug discovery has spurred advances in rational structure-based drug design and has fostered collab- orations between industry academic scientists with complementary areas of expertise in a variety of biology and chemistry discipl

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