These issues compromise the ability of platelet gels for sustained function in regenerative medicine. In the present study, a combination of platelet gels with silk fibroin gel was studied to address the above limitations. Mixing sonicated silk gels with platelet gels extended the release of growth factors without inhibiting gel-forming ability. The released growth factors
were biologically active and Selleck PFTα their delivery was modified further by manipulation of the charge of the silk protein. Moreover, the silk gel augmented both the rheological properties and compressive stiffness of the platelet gel, tuned by the silk concentration and/or silk/platelet gel ratio. Silk-platelet gel injections in nude rats supported enhanced
cell infiltration and blood vessel formation representing a step towards new platelet gel formulations with enhanced therapeutic impact. (C) 2014 Elsevier Ltd. All rights reserved.”
“Anthocyanin extracts (AEs) from Ocimum tenuiflorum (leaf), Hibiscus rosa-sinensis (petal) and this website Hibiscus sabdariffa (calyx) were investigated and compared for in vitro antioxidant activity and DNA damage protective property. Total phenolic content (TPC) and total anthocyanin content (TAC) of the AEs were determined and the major anthocyanins were characterised. In vitro antioxidant activities were assessed by ferric-reducing antioxidant power (FRAP) assay, 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical-scavenging activity, 2-deoxy-D-ribose degradation assay and
lipid peroxidation assay. The protective property of the AEs was also examined against oxidative DNA damage by H2O2 and UV using pUC19 plasmid. All the AEs particularly those from O. tenuiflorum demonstrated efficient antioxidant activity and protected DNA from damage. Strong correlation between antioxidant capacity and TPC and TAC was observed. Significant correlation between antioxidant capacity and TPC and TAC ascertained that phenolics and anthocyanins were the major contributors of antioxidant activity.”
“To reduce resting www.selleckchem.com/products/crenolanib-cp-868596.html blood pressure, a minimum isometric exercise training (IET) intensity has been suggested, but this is not known for short-term IET programmes. We therefore compared the effects of moderate- and low-intensity IET programmes on resting blood pressure. Forty normotensive participants (22.3 +/- 3.4years; 69.5 +/- 15.5kg; 170.2 +/- 8.7cm) were randomly assigned to groups of differing training intensities [20%EMG(peak) (~23%MVC, maximum voluntary contraction, or 30%EMG(peak) (~34%MVC)] or control group; 3weeks of IET at 30%EMG(peak) resulted in significant reductions in resting mean arterial pressure (e.g. -3.9 +/- 1.0mmHg, P smaller than 0.001), whereas 20%EMG(peak) did not (-2.3 +/- 2.9mmHg; P bigger than 0.05). Moreover, after pooling all female versus male participants, IET induced a 6.