Monthly Archives: September 2016

The excellent review by Hu and Zhang [92] highlighted that nanoparticles also have the capacity to carry combination therapies of two drugs/small molecules and have demonstrated to be particularly effective in circumventing multidrug resistance (MDR) issues in multiple cancer models. … Continue reading →

52,53 Seizures are usually resistant to medical therapy and control may only be achieved by surgery such as anatomical or functional hemispherectomy.53-55 HMEG has been seen in association with both neurocutaneous and overgrowth syndromes. Neurocutaneous associations include the linear nevus … Continue reading →

The left sciatic nerve was exposed at mid-thigh level. A crush injury was induced to the sciatic nerve for 15 sec, using a pair of microforceps. After injury, the site of crush was marked with sterilized ink. Then the overlying … Continue reading →

Alternatively, the inhibitory Cisplatin purchase effect of N-BPs on the mevalonate pathway can be shown by detecting accumulation of the unprenylated form of the small GTPase Rap1A, which acts as a surrogate marker for inhibition of FPP synthase and which … Continue reading →

Boldly put, “facts are ventriloquists’ dummies. Sitting on a wise man’s knee they may be made to utter words of wisdom; elsewhere, they say nothing, or talk nonsense, or indulge in sheer diabolism” (quote attributed to Aldous Huxley). Science advances … Continue reading →

Operation techniques All operations were performed by the same surgical team, which included TZ, GZ, and ZL and all of whom had experience in minilaparotomy and laparoscopic approaches to rectal cancer. All patients underwent TME with preservation of the hypogastric … Continue reading →

The first systematic discussion of the relationship between physical and psychological stress dates back to World War I. The history of that discussion provides an informative context for current controversies concerning PTSD and TBI.1 Combat techniques in World War I … Continue reading →

affected by sex or have a weak tendency toward slower elimination in women. Sex also does not. significantly contribute to the observed free (unbound) fraction of many benzodiazepines, but several reports suggest, higher plasma levels of diazepam in women,104,114 although, … Continue reading →

No antagonism was seen with the rifampicin-doxycycline or rifampicin-tetracycline combinations at both pH conditions, while antagonism was clear when the ciprofloxacin-tetracycline and ciprofloxacin-streptomycin combinations were assessed. In addition, antagonism increased at pH 5.0 compared to pH 7.0 when rifampicin-ciprofloxacin and … Continue reading →

For instance, in environments with a lower risk of being sued, doctors may rely on different medical heuristics. In Switzerland, where litigation is less common, only 41% of general practitioners and 43% of internists reported that they sometimes or often … Continue reading →