Monthly Archives: December 2016

First, impairments in neurocognition are core features of schizophrenia. These impairments are present during acute exacerbations of the illnesses and during periods of remission. In addition, first- and secondgeneration antipsychotics are relatively ineffective at treating these symptoms. Patients treated with … Continue reading →

6. Conclusions ESI-MS analysis of lipid is the most prominent approach and has enjoyed the most success in lipidomics. With great efforts of the researchers in the field, a complete quantitative analysis of lipid classes, subclasses, and MEK inhibitor individual molecular … Continue reading →

Aspects of the Incentive-Sensitization theory, with its emphasis on neurobiological changes paving the way to more persistent drug use, can only be tested in longitudinal/prospective studies of drug users and HCs, that are currently not available, but it stresses the … Continue reading →

However, recent evidence supports the notion that a subpopulation of activated glial cells may be deleterious in PD, particularly for highly dysfunctional neurons that are metabolically compromised. Strong support for this hypothesis came from a study of young drug addicts … Continue reading →

It’s God’s will, he has a plan for all of us and we can do nothing” [Iqbal]. Humour coping This was typical of males. They reported that they made fun of themselves in front of friends before their friends could … Continue reading →

This issue should be carefully considered when trying to parse out differences in ethanol drinking between mice of different genetic backgrounds. Since differences in ethanol metabolism can alter blood ethanol levels, we examined ethanol clearance. The only major difference in … Continue reading →

The results of our study are in accordance with the three pattern framework of body image coping (avoidance, appearance fixing, and acceptance) (Cash et al., 2005). Females reported use of intropunitive avoidance; they stopped going to weddings, stopped meeting old … Continue reading →

The neurogenesis hypothesis of depression assumes that neurogenesis is influenced negatively by stressful experiences and positively by antidepressant treatment. Alterations in neurogenesis are believed to play a decisive role in the pathology and treatment of major depression3,5; this view is … Continue reading →

In the early 1950s, for example, chlorpromazine was synthesized by Charpentier at Rhone-Poulenc.The surgeon Henri Laborit used the compound to induce a state of “artificial hibernation” and in 1952 forecast its potential for use in psychiatry. In that year, benefits … Continue reading →

The discovery of clozapine, and drugs like it, led to the dopamine hypothesis of schizophrenia,1 which had a high impact on the search for neurotransmitter functions. However, the pathophysiology of schizophrenic symptoms and the related mechanism of action of antipsychotics … Continue reading →