Curcumin has also been proven to quench reactive oxygen species and scavenge superoxide anion radicals and hydroxyl radicals and strongly inhibits nitric oxide manufacturing by down regulating inducible nitric oxide syn thase gene expression. Curcumin inhibits of phase I enzymes systems include cytochrome P450 isoforms, the P450 reductase, the cytochrome b5 as well as the epoxide hydrolase and protect through the toxic results of chemicals and carcinogens. On the flip side curcumin induces phase II enzymes, which perform a protective role by elimi nating toxic substances and oxidants and conferring ben efit within the prevention within the early phases of carcinogenesis. Curcumin can act like a potent immunomodulatory agent that will modulate the activation of T cells, B cells, macro phages, neutrophils, purely natural killer cells, and dendritic cells.
Curcumin may also down regulate the expression of several professional inflammatory cytokines like selleck chemical TNF, IL one, IL two, IL six, IL 8, IL twelve, and chemokines, more than likely by inactivation of the transcription factor NFB. Interestingly, even so, curcumin at very low doses may also boost antibody responses. Curcumin continues to be proven to activate host macrophages and pure killer cells and modulate of lymphocyte mediated func tions. Scientific studies from our laboratory showed that cur cumin neutralized tumor induced oxidative anxiety, restored NF kB action, and inhibited TNF manufacturing, therefore minimizing tumor induced T cell apoptosis. Even more function suggests that curcumin assists in T cell sur vival the two in main and effecter immune compartments of tumor bearing hosts by normalizing perturbed of Jak three Stat five action by means of restoration of IL2 receptor c chain expression.
Curcumin was discovered to prevent tumor induced loss of T effector cells, reverse kind two cytokine bias and blocks T regulatory selleck chemicals cell augmentation in tumor bearing hosts by means of down regulation of TGF in cancer cells. From every one of these observations it truly is sug gested that curcumin may very well be made use of alone or can be com bined with classical anti tumor drugs so as to sustain the immune capacity of the host, which might be impacted through the condition or the treatment or may be the both. Curcumin a multiple edged sword Above discussions about the broad biological exercise of this phytochemical prove our hypothesis that curcumin asserts its anti tumor exercise in cancer cells by altering the deregulated cell cycle through cyclin dependent, p53 dependent and p53 independent pathways.
Such influences of curcumin on critical signal transduction pathways
of cell cycle and effectiveness in animal model programs have qualified it being a a variety of edged sword in com bating the deadly condition cancer. Provided that disruption of cell cycle plays a crucial role in cancer progression, its modulation by curcumin seems to be a logical method in controlling carcinogenesis.