Although mucins provide molecular targets for immune system’s tumour recognition, their characteristics dictate that the nature of immune response required for recognition and lyses of mucin-expressing tumours needs to follow predominantly a MHC-unrestricted
αβ TCR-mediated effector cell response. Silmitasertib cost Frequent loss of dendritic cells maturation and elimination of reactive lymphocytes altered adhesive and anti-adhesive properties of the mucins, promote tumour survival and escape from the immune response. Mucins are expressed by epithelial cells lining gastrointestinal and urogenetal tracts and glandular organs [1]. Expression of mucin is cell- and tissue specific, and any alteration is taken as an indication of loss of tissue homoeostasis [2]. Several studies, including our own, have characterized the shift in the mucin expression and its glycosylation pattern during carcinogenic transformation and used it as a biomarker for transformation [3-5]. Besides, presence of immunodominant tandem repeats and unique and altered glycosylation patterns makes it an ideal candidate for development of cancer vaccines [6]. Nevertheless, development of tolerance to mucin immunization due to functional pliotrophism exhibited by mucins called for fresh studies that evaluated the immune regulative role
of mucins to augment the cancer vaccine designs [7]. This review overviews the mucin-dependent MLN8237 ic50 immune modulations to appreciate the basis behind tumour immunoevasion and vaccine development. Mucin
forms the crucial link that translates injury-mediated reactionary environment into a sustained genetic/physiological response that is pivotal to the initiation and progression of cancers. Persistent injury or infection activates lymphocytes to secrete pro-inflammatory cytokines that results in constitutive mucin sensing and aberrant expression [8]. These aberrations arise as a consequence of the deregulation of expression of mucin core proteins and the enzymes that modify them, during the transformation of tumour cell [9, 10]. Transformation-related changes in Calpain mucin glycosylation and constitutive expression are therefore an inherent property of epithelial cancers [10]. The nature of cytokine profile, the degree and duration of inflammation have a profound effect on mucin expression and play a causative role in initiating mucin-dependent oncogenic cell signalling and immunomodulation. The cell-specific and cytokine-dependent expressions of mucins are indeed natural healing processes subverted to aid the tumour formation and progression in an aberrant environment [11]. Cancer-associated mucin glycosylation is characterized by a general reduction of glycosylation and truncation of O-linked glycans [12, 13] (Fig. 1).