05). Four patients failed to show
improvement of their asthma after surgery. Postoperative complications in the form of chest infection, wound sepsis, burst abdomen were reported Birinapant in 8 of the patients who have had surgery. Over correction of incompetent cardia was seen in 4 patients and responded well to balloon dilatations. Death attributed to surgical interference was not recorded in this series. Conclusion: Conclusion This study showed that control of GERD in patients with GERD induced asthma is mandatory and also highlighted that surgical treatment of GERD substantially improves patients with GERD induced asthma when medical therapy could not be maintained and should be considered in patients with GERD induced asthma. Key Word(s): 1. GERD; 2. Asthma; 3. fudoplication; Presenting Author: XIAOYONG WANG Additional Authors: LENING XUE, KEQUN XU Corresponding Author: XIAOYONG
WANG Affiliations: Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University IWR-1 in vivo Objective: The intensity of the inflammation induced by H. pylori is associated with the development of gastric cancer. The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses. Toll like receptors (TLR) play an essential role in innate immunity, being involved in regulation of inflammatory reactions and activation of the adaptive immune response to eliminate harmful pathogens. The aim of the study was to investigate the relationship between TLR4 Asp299Gly, TLR4 Thr399Ile and TLR9 T-1486C polymorphisms and gastric cancer risk in an Chinese population. Methods: We performed a case–control study of 314 histologically confirmed gastric cancer patients and 314 age, sex frequency-matched cancer-free controls in a Chinese population. TLR4 and TLR9 polymorphisms
were genotyped by the PCR-RFLP method. H. pylori infection status was determined by a validated serological test. Odds ratios were computed from logistic models and adjusted for potential confounding factors. Results: H pylori seropositivity is increased selleck kinase inhibitor in gastric carcinoma patients compared with a control with an OR of 1.51 (95% CI, 1.07 to 2.13, P = 0.02). No homozygous or heterozygous variant genotypes of the Asp299Gly and Thr339Ile polymorphisms were detected in case and control. Genotype frequencies of the TLR9 T-1486C polymorphisms among controls were in Hardy-Weinberg equilibrium (P > 0.05). Multivariate logistic regression analyses revealed that subjects carrying the TC or CC genotype had an OR of 1.47 (95% CI, 1.04–2.10) and 1.63 (95% CI, 1.01–2.64) for developing GC, respectively, compared with subjects carrying the TT genotype. Further stratification analyses based on the dominant models reveal that a significantly increased risk of gastric cancer associated with the C carriers was evident among female (adjusted OR, 1.84; 95%CI, 1.02–3.