(2013), under the heading ‘Comparing the lateralization of posture effects across experiments’ (pp. 2889–2890), there was an error in the reporting of the Monte Carlo simulation. The simulation was performed between 128 and 200 ms (and not between 0 and 200 ms), and the significant effect started at 168 ms, and not at 152 ms as printed. The authors regret
this error. INCB024360 The following is the correct reporting of this analysis: The Monte Carlo simulation was performed between 128 and 200 ms and the significant effect of sight of the limbs (the variable manipulated between the two experiments) on the laterality of postural remapping started at 168 ms, and was observed until the end of the interval tested, i.e., 200 ms (a sequence of consecutive significant t-tests, all P < 0.05, over 18 ms in length was deemed significant). The mean first-order autocorrelation at lag 1 was 0.96. "
“The quest for possible targets for the development of novel analgesics has identified the activation of the cannabinoid type 1 (CB1)
receptor outside the CNS as a potential means of providing relief from persistent pain, which currently constitutes an unmet medical need. Increasing tissue levels of the CB1 receptor endogenous ligand N-arachidonoylethanolamine (anandamide), by inhibiting anandamide degradation through blocking the anandamide-hydrolysing enzyme fatty acid amide hydrolase, has been suggested to be used to activate the CB1 receptor. However, recent clinical trials revealed that this approach does not deliver the expected relief from pain. Here, we see more discuss one of the possible reasons, the activation of the transient receptor potential vanilloid type 1 ion channel (TRPV1) on nociceptive primary sensory neurons (PSNs) by anandamide, which may compromise the beneficial effects of increased tissue levels of anandamide. We conclude that better design such as concomitant blocking of anandamide hydrolysis and anandamide uptake into PSNs, to inhibit TRPV1 activation, could overcome these problems. “
processes there are extensive interactions between various regions of the cerebral cortex. Oscillations in Ergoloid the gamma frequency band (≈40 Hz) of the electroencephalogram (EEG) are involved in the binding of spatially separated but temporally correlated neural events, which results in a unified perceptual experience. The extent of these interactions can be examined by means of a mathematical algorithm called ‘coherence’, which reflects the ‘strength’ of functional interactions between cortical areas. The present study was conducted to analyse EEG coherence in the gamma frequency band of the cat during alert wakefulness (AW), quiet wakefulness (QW), non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. Cats were implanted with electrodes in the frontal, parietal and occipital cortices to monitor EEG activity.