Conclusion: Shenling baizhusan can protect the damage in dextran sodium sulfate-induced IBD in mice,which
may be related to regulating inflammatory factor, scavenging oxygen free radicals and regulating ROCK/MLCK and MAPK/ERK pathway. Key Word(s): 1. Shenling baizhusan; 2. IBD; 3. ROCK/MLCK; 4. MAPK/ERK; Presenting Author: PENG YOU Additional Authors: JIANGYUAN WANG, YULAN LIU Corresponding Author: YULAN LIU Affiliations: Department of Gastroenterology,Peking University People’s Hospital Objective: To explore the current situation of medical therapy and compliance of ulcerative colitis (UC) patients in China. Methods: 258 cases (123 male and 135 female) of UC admitted to our hospital from all over China in the last PLX3397 mw 5 years were retrospective analyzed. Selection and delivery route of drugs in both initial and maintenance therapy and the adherence of patients were analyzed. Results: (1) The average age of onset is 41 years in male and 37 years in female. The average time from onset to definite diagnosis ranges from 0.2 to 312 months (14.6 months in average). (2) The highest percentage of drugs in initial therapy is quinolones, up to 39.3%, with an effective rate of 72.3%. The drug selection of oral SASP, oral 5-ASA, oral SASP + suppository and herbs is 52%, 14.6%, 13.5% and 7.3% respectively after
diagnosis. In maintenance therapy, 75.9% of cases used SASP or 5-ASA. The percentage of oral administration, suppository, oral administration + suppository, and enteroclysis is 65.7%, 11.8%, 12% and 2.8% respectively in maintenance therapy. (3) Compliance: the nonadherence rate is 50%, 69.2% and 100% in suppository, VX 809 oral and enteroclysis administration. The drug withdrawal occurs
7.7 months after the first remission in average. The average time of relapse after drug Anidulafungin (LY303366) withdrawal is 11.9 months. The adherence rate of oral SASP, oral 5-ASA, suppository SASP and oral + suppository SASP is 35.7%, 24.1%, 11.6% and 10.7% respectively. Conclusion: (1) The diagnosis of UC is mainly based on colonoscopic examination, which should be performed earlier when UC is suspected. (2) There is a poor adherence rate of maintenance therapy when symptoms are relieved. Drug withdrawal mostly occurs half years after symptom remission. So follow-up and education of patients at that time is important. (3) SASP is very effective in maintenance therapy, and 5-ASA is not prior to SASP in compliance rate. SASP may have better cost efficient in China. Key Word(s): 1. ulcerative colitis; 2. medical therapy; 3. compliance; Presenting Author: WENYU JIANG Additional Authors: XIAOFEI ZHANG, HONGJIE ZHANG Corresponding Author: HONGJIE ZHANG Affiliations: The First Affiliated Hospital of Nanjing Medical University Objective: Inflammatory bowel disease (IBD) was believed to be caused by excessive and poorly controlled immune response. Experimental studies and data from recent clinical trials suggested that T cell-derived cytokines are crucial mediators of tissue damage.