, MD (Early Morning Workshops) Consulting: Abbott, Actelion, Boerringer-Ingelheim, Cempra, Genzyme, Roche, Merck, Medicine COmpany, Momenta, Janssen, Novartis, Otsuka, Pfizer, Sanolfi, mTOR inhibitor Takeda, UCB, Bristol-Myers Squibb, GSK Watt, Kymberly D., MD (General Hepatology Update, Meet-the-Professor Luncheon, Professional Development Workshop, Transplant Surgery Workshop) Nothing to disclose Wells, Rebecca G., MD
(AASLD Postgraduate Course, Basic Research Workshop, State-of-the-Art Lecture) Nothing to disclose Wolkoff, Allan W., MD (SIG Program) Grant/Research Support: Merck Wong, Florence, MD (AASLD Postgraduate Course, Early Morning Workshops, General Hepatology Update, Meet-the-Professor Luncheon, Parallel Session, SIG Program) Consulting: Gore Inc Grant/Research Support: Grifols Wright, Elizabeth C., PhD (Clinical Research Roxadustat in vivo Workshop) Nothing to disclose
Wright, Teresa L., MD (Career Development Workshop, Professional Development Workshop) Employment: Genentech, Roche, Roche, Roche Yee, Hal F., MD, PhD (Global Forum) Nothing to disclose Zeybel, Mujdat, MD (SIG Program) Nothing to disclose Zoulim, Fabien, MD (Parallel Session, SIG Program) Advisory Committees or Review Panels: Janssen, Gilead, Novira, Abbvie, Tykmera, Transgene Consulting: Roche Grant/Research Support: Novartis, Gilead, Scynexis, Roche, Novira Speaking and Teaching: Bristol Myers Squibb, Gilead Zucman-Rossi, Jessica, MD, PhD (State-of-the-Art Lecture) Grants/Research Support: Integragen Consulting: Pfizer Speaking and Teaching: Bayer, Lilly Advisory Board: Astellas, Celgene “
“We report a case of idiopathic portal hypertension (IPH) complicated with autoimmune hepatitis. A 60-year-old woman was admitted to our hospital with esophageal and gastric varices in February 2010. Abdominal ultrasonography
and computed tomography showed splenomegaly and collateral veins without evidence of liver cirrhosis. Laboratory examinations and liver biopsy indicated that the esophageal and gastric varices were caused by IPH. She underwent endoscopic injection sclerotherapy and partial splenic embolization. Two years after these therapies, Fludarabine chemical structure laboratory examinations showed liver dysfunction with elevated levels of aspartate aminotransferase (180 IU/L), alanine aminotransferase (190 IU/L), γ-glutamyl transpeptidase (159 IU/L) and immunoglobulin G (2609 mg/dL). The titer of antinuclear antibodies was 1:320 and its pattern was homogeneous and speckled. Histological examination revealed plasma cell/lymphocyte infiltration and interface hepatitis in the portal tract. Based on these findings, a diagnosis of autoimmune hepatitis accompanied by IPH was made. After treatment with prednisolone (20 mg/day), liver functions were normalized immediately. Overlapping of IPH and AIH is extremely rare, but the present case is interesting considering the etiology of IPH because an autoimmune mechanism is thought to be involved in the pathogenesis of IPH.