We found sensitivity and specificity
for Plmax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables Plmax, PEmax and SNIP can identify selleckchem differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, Plmax and PEmax. Conclusion: In ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.”
“Objective: To assess whether liraglutide, a glucagon-like peptide-1 receptor
agonist, has cardioprotective properties in addition to its glycemic effects.
Methods: click here We performed a retrospective analysis of medical records of 110 obese patients with type 2 diabetes mellitus treated with liraglutide for at least 6 months between March 2010 and April 2011 at our tertiary care referral center. The variables analyzed were body mass index, hemoglobin A(1c) (A1C), systolic blood pressure (SBP), plasma C-reactive protein (CRP) concentrations, and serum lipids.
Results: In our overall study cohort, we noted a reduction in mean weight from 120 +/- 5 kg to 115 +/- 3 kg and a decrease in mean A1C from 7.8% +/- 0.6% to 7.2% +/- 0.2%. The mean triglyceride concentration decreased from 173 +/- 19 mg/dL to 151 +/- 15 mg/dL, the mean SBP was reduced from 132 +/- 6 mm Hg to 125 +/- 4 mm Hg, and the mean CRP concentration declined from 4.7 +/- 0.8 mg/L to 3.2 +/- 0.4 mg/L after treatment with liraglutide for a minimal duration of 6 months and a mean duration of 7.5 months (for all the foregoing changes, P <.05). These variables decreased whether these patients were previously treated with orally administered hypoglycemic agents
alone or in combination with insulin or exenatide.
Conclusion: Our findings in a clinical practice show that liraglutide is a potent antidiabetes drug, whether given Selleck GKT137831 in combination with orally administered agents or insulin or as a substitution for exenatide. It lowers body weight, A1C levels, SBP, and CRP and trialyceride concentrations. (Endocr Pract. 2012;18:140-145)”
“Background: Dysautonomia after severe traumatic brain injury (TBI) is a clinical syndrome affecting a subgroup of survivors and is characterized by episodes of autonomic dysregulation and muscle overactivity. The purpose of this study was to determine the incidence of dysautonomia after severe TBI in an intensive care unit setting and analyze the risk factors for developing dysautonomia.