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“Intracranial flow diverting devices are increasingly used to treat cerebral aneurysms. A reliable, non-invasive follow-up modality would be desirable. Our aim was to compare intra-arterial digital subtraction find more angiography (ia DSA) to angiographic computed tomography with intravenous contrast agent application (iv ACT) in the visualisation of flow diverting devices
and aneurysm lumina.
Follow-up monitoring by iv ACT (n = 36) and ia DSA (n = 25) in 14 patients treated with flow diverting devices for intracranial aneurysms was evaluated retrospectively. Images were evaluated by two neuroradiologists in anonymous consensus reading regarding the device deployment, wall apposition, neck coverage of the aneurysm, opacification of the vessel and device lumen, as well as the degree of aneurysm occlusion.
Corresponding ia DSA and iv ACT NVP-BSK805 research buy images were scored identically in all patients regarding the stent deployment, wall apposition and neck coverage, as well as the degree of aneurysm occlusion and patency status of the device and parent artery. Opacification of the parent vessel lumen and perfused parts of the aneurysm was considered slightly
inferior for iv ACT in comparison with ia DSA (seven of 36 cases), without impact on diagnosis.
We demonstrated the feasibility and diagnostic value of iv ACT in follow-up imaging of intracranial flow diverting devices. Due to its high spatial resolution and non-invasive character, this novel technique might become a valuable imaging modality in these patients.”
“Objective:
Surgical ventricular reconstruction is a treatment option for patients with apical akinesia or dyskinesia. The Surgical Treatment for Ischemic Heart Failure trial recently demonstrated its safety but no added benefit to bypass surgery, although the trial’s inclusion criteria did not contain shape or viability parameters. However, we evaluated cardiac magnetic resonance-derived parameters as potential predictors of PTK6 function after surgical ventricular reconstruction.
Methods: In 24 patients with cardiac magnetic resonance before and after surgical ventricular reconstruction, we assessed cardiac volumes, function, scar, and geometry (sphericity index, short to long axis; apical conicity index, apical to short axis; apical volume index, apical to basal volume).
Results: Surgical ventricular reconstruction significantly reduced ventricular volumes (-64.2%) and increased global ejection fraction by 12% (P < .01). The sphericity index was increased by surgical ventricular reconstruction (0.60 +/- 0.07 vs. 0.76 +/- 0.13. P < .05) indicative of ball shapes. The apical to short axis (0.71 +/- 0.13 to 0.58 +/- 0.09) and apical to basal volume (0.45 +/- 0.08 to 0.26 +/- 0.11) decreased, consistent with aneurysm removal. The preoperative ventricles contained 25% +/- 14% of scar (apical: 72% +/- 8%, midcavity: 38% +/- 14%, basal region: 10% +/- 12%).