Anti-CD3 Anti-AKT antibodies such as teplizumab are engineered to block the function of CD3 cells

acroGenics and Dr. Herold have the opportunity to move anti-CD3 research forward significantly said Richard Insel, M.D., JDRF Executive Vice President for Research. “At this time, Anti-AKT Antibody treatment is the only developed method of changing the clinical course of new onset type 1 diabetes. Because it preserves beta cell function in newly diagnosed patients, it has the potential to decrease insulin requirements, lead to better glucose regulation, and decrease short-term and long-term complications of diabetes. Furthermore, JDRF is especially excited about our partnership with MacroGenics because the Protege trial is one of the first Phase III trials we’ve ever funded.”Anti-CD3 antibodies such as teplizumab (MGA031, hOKT3-gamma-1 (Ala-Ala)) are engineered to block the function of CD3 cells, immune T cells that orchestrate the destruction of islets. The antibodies prevent “activation” of the T cells after they have identified their target, disarming them once they are poised to attack. Teplizumab is a humanized monoclonal antibody that binds to an epitope of the CD3-epsilon chain expressed on mature T cells.

In a June 2005 publication in the journal Diabetes, Dr. Herold reported two-year follow-up data for 21 subjects who received a single course of hOKT3- gamma-1 (Ala- Ala) within six weeks of their diagnosis of type 1 diabetes. The patients who received hOKT3-gamma-1 (Ala-Ala) had improved C-peptide responses following a mixed meal tolerance test, reduced hemoglobin A1c (HbA1c) levels, and lower insulin requirements for at least two years following the initial treatment compared to the control population. C-peptide responses measure a patient’s residual beta cell function and ability to produce insulin. HbA1c is a measure of metabolic control that reflects the amount of glucose in a patient’s blood over a three-month timeframe. Dr. Herold is an advisor to MacroGenics for further clinical testing of teplizumab.

Type 1 diabetes is an autoimmune disease in which the body’s immune system attacks and destroys the insulin-producing cells of the pancreas. Type 1 diabetes strikes suddenly, making a person dependent on injected or pumped insulin for life, and carrying the constant threat of devastating complications such as heart and kidney disease, nerve damage and blindness. As many as three million Americans may have type 1 diabetes and each year over 13,000 children are diagnosed with type 1 diabetes in the U.S. Although diagnosis most often occurs in childhood and adolescence, it can and does strike adults as well. To stay alive, people with type 1 diabetes must take multiple insulin injections daily or continually infuse insulin through a pump, and test their blood sugar by pricking their fingers for blood six or more times per day. While trying to balance insulin doses with their food intake and daily activities, people with this form of diabetes must always be prepared for serious hypoglycemic (low blood sugar) and hyperglycemic (high blood sugar) reactions, both of which can be life-limiting and life threatening. Accordingly, a treatment that aims to slow the progression of the disease has the potential to substantially improve the health and quality of life of people with recent-onset type 1 diabetes.
Statements made in this news release that are not historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “expects,” “believes,” “intends,” and similar expressions are intended to identify forward-looking statements. Actual results may differ materially from those projected in any forward- looking statement. Specifically, there are a number of important factors that could cause actual results to differ materially from those anticipated, such as the Company’s ability to raise additional capital, and risks related to the Company’s ability to initiate, and enroll patients in, planned clinical trials. You should not place undue reliance on any forward-looking statements. The Company assumes no obligation to update any forward-looking statements as a result of new information, future events or developments, except as required by law.New research from Sweden reveals that a person’s chance of having a stroke is
linked to low levels of a natural antibody in the immune system: the researchers hope to develop a vaccine that stimulates the immune system to boost levels of the a AKT Antibody and thus increase the body’s own defences against arteriosclerosis and stroke.The subjects were part of population-based cohorts recruited between 1985 and 1999 to take part in the V?sterbotten Intervention Project (VIP) and the World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease (WHO MONICA) project in Northern Sweden.OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics that target cancer stem cells, announced the publication of preclinical data demonstrating that its lead candidate, OMP-21M18, inhibits tumor growth and reduces cancer stem cell frequency when administered alone or in combination with chemotherapy in human colorectal cancer tumors with or without KRAS mutations. This study was published in the March 1, 2011 issue of Cancer Research, a publication of the American Association of Cancer Research.

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