Catecholamines One of the
key factors in the management of TBI is maintenance of cerebral perfusion pressure and cerebral blood flow, and systemic administration of catecholamines is often used to achieve this. Circulating endogenous catecholamines are increased in TBI due to stimulation {Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| of the sympatho-adrenal axis. Endogenous circulating catecholamines are a readily quantifiable marker that predicts the outcome in TBI [52, 54]. It has been shown in rodents that optimal synthesis of catecholamines in the brain is critical to a working memory. TBI results in activation of tyrosine hydroxylase (TH) in the brain. This is the rate limiting step in catecholamine synthesis and changes in activation find more of TH result in altered catecholamine signalling in the prefrontal cortex which impacts on memory [55]. Neurotrophins Neurotrophins are normally found in cell bodies and the projections of neurons, and they facilitate neuronal survival and differentiation [56, 57]. They include nerve growth factor (NGF),
brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4) and neurotrophin-5 (NT-5). Of the neurotrophic agents, BDNF shows the most promise in the future management of brain injury. Animals treated with BDNF following TBI, showed an improvement in cognitive function and regeneration of the neural network which resembled developmental neuroplasticity. This was directly related to improvement in synchronized movement and spatial orientation [58, 59]. Unfortunately there is no convincing evidence for the use of these
drugs in humans [60]. Conclusion This review emphasises that the molecular mechanisms underlying secondary brain damage following TBI are complex. Our understanding of these mechanisms has increased significantly in recent years, but is far from complete. Advances in the acute management of TBI, is likely to be dependant both on an improved understanding of these mechanisms, as well as the translation of such knowledge into the development of new molecules and techniques to improve the clinical outcome. References 1. Sultan HY, Boyle A, Pereira M, Antoun N, Maimaris C: Application Fossariinae of the Canadian CT head rules in managing minor head CYT387 cell line injuries in a UK emergency department: implications for the implementation of the NICE guidelines. Emerg Med J 2004,21(4):420–5.CrossRefPubMed 2. Fleminger S, Ponsford J: Long term outcome after traumatic brain injury (Editorial). BMJ 2005, 331:1419–20.CrossRefPubMed 3. Langlois JA, Rutland-Brown W, Thomas KE: Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta (GA): Centers for Disease Control and Prevention. National Center for Injury Prevention and Control 2004. 4. Burdens of disease a discussion documentLondon: Department of Health, NHS Executive 1996. 5. Perel P, Edwards P, Wentz R, Roberts I: Systematic review of prognostic models in traumatic brain injury.