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Base for Pharmacogenomics ABCB1, access number is the number of new F lle Of malignant brain tumors increased significantly in the past two decades. Epothilone A In 2010 would be beautiful diagnosed tzungsweise 22,000 new patients and 13,000 patients die of brain tumors in the United States. Primary brain tumors and metastatic brain tumors Ren: k brain tumors can be divided into two categories below. Prim Arise re brain tumors in the brain and usually not metastasize. These tumors represent only 2 of all cancers, but make a unverh Ltnism Moderately high proportion of morbidity t t and mortality. Metastatic brain tumors originate au Outside the central nervous system to the rest of the K Rpers and spread to the brain metastases.
Metastatic brain tumors develop 10 30 of patients with cancer, AS-605240 and are the hours Most frequent type of brain cancer, with more than four times gr Eren impact compared to annual rates prim Ren brain tumors. The incidence of brain metastases in the last decade te primarily to the improved treatment of Prim Rtumoren Ger With erh Erh hte survival rate of patients Ht, and the fact that the development of new tools for image and recognizing CNS tumors. Despite intensive research, the treatment of metastatic brain tumors is largely ineffective and diagnosis of brain tumors is always fatal. A large e challenge for researchers is now effective delivery of anti-cancer drugs in prime Ren and metastatic tumors of the CNS. The gr Te obstacle to the successful delivery of drugs into the central nervous system, the blood-brain barrier.
The BBB is an interface between the endothelial blood-brain and the central nervous system shields against the effects of circulating toxins and potentially beautiful dlichen chemicals. At the same time eventually t this protective barrier therapeutic drugs into the brain, and is a barrier for drugs against diseases of the central nervous system, how to treat brain cancer. At the molecular level, endothelial cells of the brain capillaries that make up the BBB interconnected by tight junctions, which limit the passage of gel Most materials in the parazellul Ren brain. Movement of gel Most substances can not. Into the brain by passive diffusion, absorption and transport The BBB will continue because the ATP-binding cassette efflux transporters Limit xenobiotics, including normal of many therapeutic drugs into the brain of verst RKT.
P-glycoprotein and breast cancer resistance protein are two prominent members of the superfamily of ABC transporters. Have both wide and partially overlapping substrate specificity Th a plurality of structurally different drugs currently in clinical use include. Both airlines wear are an integral part of the defense mechanism of protection of the BBB, by making access to medicines in the brain and thus invalid. Moreover, schl Gt recent literature that nken P gp and BCRP team and work together to the BHE to Descr brain penetration of drugs. This