Fluorouracil Adrucil compared genetically with the Mann-Whitney-Wilcoxon test

Dy as a substitute for plo The DNA. StatisticalMethods The Fluorouracil Adrucil prime Re endpoint was the time to biochemical failure as from Roach et al. be a rise in PSA of at least 2 postradiation ng / mL above the nadir value. Differences in the PGA between the groups were compared genetically with the Mann-Whitney-Wilcoxon test. Calculated in accordance with an accepted standard of reporting trials in prostate cancer five years after biochemical recurrence-free rates were the Kaplan-Meier method and used everywhere. The log-rank test was used to assess the relationship between celebrity status and HSD17B2 with bRFR. In the multivariate analysis of StAR Ver Alteration and allelic HSD17B2 also adjust for clinical factors with the Cox model were tested. The Fisher exact test was used to study the statistical Zusammenh length Between the star and HSD17B2. P value of 0.05 was used to assess statistical significance. RESULTS allelic Lossesof AreCommonEvents StARandHSD17B2Loci in the medium risk ProstateCancer As genes in the androgen axis k Can new prognostic factors, we first determined the H FREQUENCY loss or gain of alleles at each site. Allelic Ver Changes were observed mainly at loci with star and HSD17B2. In the evaluation of 126 biopsies of aCGH, 27/126 or 21% of patients with intermediate risk appears to be an allelic loss of loci star, w While 32/126 or 25% of patients had allelic loss of loci HSD17B2 displayed. The validation of these results was by analysis of the data base Memorial Sloan Kettering Cancer of the prostate, which carried out 131 patients, the surgery intermediaterisk included. Surgery in this cohort 34/131 or 26% of patients showed an allelic loss of All Star 28/131 or 21% of patients showed allelic loss of HSD17B2. Thus, the frequency Changes Like in our group of patients are observed for radiation therapy. Interestingly, the 33 loci, the genes are shown in our study, only very few changes from a significant number Shown in this cohort of 126 patients radiotherapy. In addition, radiation therapy in patients showed a loss of StAR loci 13/27 or 48.1%, a loss of HSD17B2 loci. Allelic Lossesof the AreCorrelatedWith StARandHSD17B2Loci erh Ht Genome Alteration We calculated the relative percentage of genetic instability T in tumor DNA of each sample with the PGA. Tumor samples with allelic loss of star and HSD17B2 loci were significantly h Forth in comparison to the PGA tumor samples without loss of these loci associated. If the subgroup of patients with Gleason score and StAR/HSD17B2 condition, we observed that samples with Ver Changes in both star and HSD17B2 associated GW786034 with an increase in the PGA as a Gleason score 6 and 7 cancers were compared to those have not lost the star and HSD17B2 loci. These trends were also observed in the subgroup of patients with pretreatment PSA and T category. Tumor samples with a significant independent Ngiger Pr Predictor allelica by clinical factors modeling of PSA, Gleason score and T category LOH loci with individual HSD17B2 was also a significant independent Ngiger Pr Predictor for modeling with clinical factors, but less than STAR . Closing Lich had LOH of loci, the star and / or a HSD17B2.