Furthermore, the post-mitochondrial
caspase-3 was quantified using ELISA. In view of our results, goniothalamin induced apoptosis on treated cells via alteration of cellular membrane integrity and cleavage of DNA. On the other hand, post-mitochondrial caspase-3 activity was significantly elevated in HepG2 cells treated with goniothalamin after 72h. These findings suggest SB273005 that goniothalamin induced apoptosis on HepG2 liver cancer cells via induction of caspase-3 with less sensitivity on the cell line of Chang cells.”
“We present an extensive study of the exchange bias properties and glassy behavior in low-doped La1-xSrxCoO3 cobaltites. The temperature dependences of the dc magnetization and ac susceptibility indicate that the spin glass state exists even at high magnetic fields. The field-cooled magnetic hysteresis loops exhibit both horizontal and vertical shifts. The vertical shift decreases selleck products with increasing the measuring field and approaches zero around 40 kOe, while the horizontal shift still exist even at 80 kOe. It is suggested that these two shifts may have different
origins. The cooling- field dependence of the training effect was measured and analyzed by the power law and a spin configuration relaxation model. The results show that the suppression of the spin glass state region with increasing cooling fields plays the most important role in the decrease of the exchange bias field. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3123812]“
“Chromosome rearrangements involving telomeres have been
established as one of the major causes of idiopathic mental retardation/developmental delay. This case of 7p partial trisomy syndrome in a 3-year-old female child presenting with developmental delay emphasizes the clinical relevance of cytogenetic diagnosis in the better management of genetic disorders. Application of subtelomeric FISH technique revealed the presence of interstitial telomeres and led to the ascertainment of partial trisomy for the distal 7p segment localized on the telomeric end of the short arm of chromosome 19. Whole-genome SN-38 ic50 cytogenetic microarray-based analysis showed a mosaic 3.5 Mb gain at Xq21.1 besides the approximately 24.5 Mb gain corresponding to 7p15.3- > pter. The possible mechanisms of origin of the chromosomal rearrangement and the clinical relevance of trisomy for the genes lying in the critical regions are discussed.”
“Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa.