In Mexico, one out of 20 Mexican men and one out of 12 Mexican women older than 50 years of age will sustain a hip fracture [5]. The rate of radiographically defined vertebral fractures in Mexican women is
high [6] (overall rate of 19.2%), but no data regarding the epidemiology of vertebral fractures in men have been published. The aim of the present study was to determine the prevalence of radiographically defined vertebral fractures by age in a random sample of Mexican men over 50 years and to identify potential AZD1152 order conventional risk factors associated with vertebral fractures in this group. Methods Study design A radiographical survey was designed for this study; 413 Mexican men were included from a population-based random sample in the city of Puebla. The random probability sample was generated with the advice of
the National CHIR98014 mouse Institute of Geography and Statistics (INEGI) in Mexico. We used the last census available to build a stratified sample of 100 men for the following age groupings: 50–59, 60–69, 70–79, and ≥80. We used the demographic information available from every district and group of households blocks within the city and we used the maps and cartography provided by INEGI during the survey. Before the study began, a training workshop was held with the interviewers to review the questionnaire and survey methods. Eligible men participated in a face-to-face interview in their homes; Atezolizumab after the interview, they were asked to have lateral X-rays of the thoracic and lumbar spine taken. If a man was unable or unwilling to participate, he was replaced by the first man available of the same age stratum, making home visits to houses from right to left of the first assigned house in the same block of households until a man who fulfilled the criteria was found. The protocol was submitted to and approved by the Institutional Review Board, and a written consent of all participants
was obtained before the interview. Questionnaire The questionnaire used was originally designed for Latin American Vertebral Osteoporosis Study (LAVOS) [6]. All questions were developed based on the questionnaires of two large studies, the European Prospective Osteoporosis Study (EPOS) and the Study of Osteoporotic Fractures (SOF) [7, 8], and collected self-reported data on demographics, lifestyle factors, and conventional risk factors for osteoporosis [9]. To assess dietary calcium, we included a semi-quantitative food questionnaire validated in Spanish for the Mexican population [10]. The Sistema de Nutrimientos (SNUT) program was used to compute dietary calcium in Adriamycin nmr milligram per day. Commercial calcium supplement intake was calculated according to names and daily doses reported by participants.