In PD-Off, the relation between the PFC BOLD activity and DAT-BP

In PD-Off, the relation between the PFC BOLD activity and Volasertib molecular weight DAT-BPND values follows a U-shaped model; in contrast, the same relation follows an inverted-U shape model in PD-On. The color bars represent T statistics. For display purposes, maps are thresholded at P < 0.005, uncorrected, but results are significant at P < 0.05, familywise error (FWE), small volume correction (svc). Coordinates (x, y, and z) are in the Montreal Neurological Institute (MNI) space. BOLD, blood oxygenated level dependent. Click Inhibitors,research,lifescience,medical here to view.(1003K, tif)
Crucifixion as a means of state-sponsored torture and execution likely began in the Persian

Empire five centuries Inhibitors,research,lifescience,medical before the birth of Christ. It was originally “designed” as a means of executing condemned

criminals without allowing their feet to touch “holy ground” (Jackson 1909; Barbet 1953; Tenney 1964). This practice spread rapidly throughout the Persian Empire (Friedrich 1971; Shrier 2002), and was adopted by nearby Indian, Scythian, Taurian, and Assyrian societies (Holoubek and Holoubek 1995). In the 4th century B.C., Alexander the Great adopted crucifixion from the Persians, introducing it to Inhibitors,research,lifescience,medical Egypt, Carthage, and the Roman Empire. In Rome, the practice rapidly flourished, evolving into a brutal means of executing revolutionaries, slaves, and foreign criminals (Roman citizens were protected from the torture except in cases of deserting soldiers) (Depasquale and Burch 1963; Hengel 1977). In the centuries that Inhibitors,research,lifescience,medical followed, many mass crucifixions were performed in the Roman Empire, often adjacent

to heavily traveled passageways to serve as warnings to foreigners and potential invaders (Edwards et al. 1986; Hoare 1994). In its earliest Persian form, the condemned were tied with rope or impaled to an upright post or tree and left to die. In Rome, however, crucifixion developed into a lengthy, torturous ceremony Inhibitors,research,lifescience,medical (Edwards et al. 1986). The condemned were initially stripped of their clothing, tied to a pole, and publicly ridiculed while flogged with a flagrum consisting of leather bands attached to metal balls or small bones (Holoubek and Holoubek 1995). After the flogging, the victim was forced to carry Drug_discovery a 75–125 pound patibulum across his shoulders to the site of crucifixion, typically located outside the city walls in view of travelers-by (Barbet 1953; Edwards et al. 1986; Hoare 1994; Holoubek and Holoubek 1995). Suffering from significant blood loss and physical else exhaustion, the condemned was then offered a mild analgesic drink of wine and myrrh and thrown back upon the patibulum to be secured. Various types of crosses were developed in Rome for this practice, including the “T-shaped” tau and “┼-shaped” Latin crosses (Barbet 1953; Davis 1965, 1976; Hengel 1977; Lumpkin 1978; Edwards et al. 1986).

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