Liver and abdomen examination during the selleck compound caesarean section revealed no metastases. Recovery from caesarean section was uneventful. As had been advised, the patient returned for surgical treatment in a private setting approximately two months after delivery. Since there was no palpable axillary lymph node,
simple mastectomy was done without any axillary clearance. Gross picture was not taken due to ignorance of Inhibitors,research,lifescience,medical the surgeon. However, we somehow managed to obtain the biopsy report, which confirmed that the mass was malignant phylloides tumor of breast. The photomicrographic view (×400) of H/E stained section shows spindle-shaped, highly pleomorphic and hyper chromatic stromal cells, and atypical tripolar mitotic figure, which had grown independent Inhibitors,research,lifescience,medical from epithelial components (figure 3). These two signs were indicative of malignancy. Figure 3 Microphotograph of malignant phylloides tumor of the breast (H&E stained ×400). Subsequent to a discussion with the surgeon of the case we came to know that the patient was recovered uneventfully after surgery, and stitches were removed on the 7th post operative day. Following discharge, the patient was asked to take advice from the Oncology Department in a higher center as no facility of radiotherapy or chemotherapy was available here in our set up. Owing to very
low education and socioeconomic Inhibitors,research,lifescience,medical condition the patient never turned up. Discussion Malignant phylloides tumor is a relatively Inhibitors,research,lifescience,medical rare tumor of the breast, constituting 0.5% of breast tumors.1 Only six previous cases of phylloides tumor in pregnancy were found, and majority was in the last trimester.3 It characteristically grows very rapidly and attains large sizes by the time of presentation.4 Rapid enlargement of the tumor in pregnancies, as seen in our case, has been previously reported.4-6 Though rare cases of bilateral Inhibitors,research,lifescience,medical malignancy have been reported,3,7 the proportion of malignant tumors amongst such lesions, as reported in literature, seems to vary considerably. Vorherr et al.8 reported that 10-30% of cases were
Anacetrapib malignant, whilst others 1 stated that as many as 33% were malignant and a further 27% were borderline. Karim et al.9 reported that 12% and 33% of cases were malignant or borderline, respectively. They commented on the pathogenesis of malignant change in cystosarcoma, and stressed the importance of loss of the stromal-epithelial interdependency, increased stromal proliferation, angiogenesis, and matrix alterations in the progression to malignancy. They also commented on the greater percentage of tumors with higher grades and higher recurrence rate in Asian women. The malignant changes arise from the stromal tissues, and hence form sarcomas. Fine needle aspiration inhibitor Lapatinib cytology has been used to detect malignancy in these tumors,10 but the definite proof requires obtain biopsy.