The AM retrieval networks involve the MK-2206 mouse medial and lateral part of the temporal, frontal, and parietal cortex as well as limbic structures. Among these regions, the medial prefrontal cortex and the precuneus are key players in self-processing during autobiographical memory retrieval. Overall, these data emphasize the need to study AM impairment and its neural underpinnings in mental disorders characterized by abnormal self-representation and impaired self-regulation of emotion.
The term “memory” generally means the ability
to reproduce or remember experienced or learned content. There Inhibitors,research,lifescience,medical are different types or constructs of memory, and the classification of memory categories is still subject to change and discussion.1 Memory may be classified as implicit or explicit: Inhibitors,research,lifescience,medical implicit memory mainly stands for nonverbal habitual memory, such as motor learning (eg, playing a musical instrument or riding a bicycle); explicit memory contains active or passive recall of facts or impressions (biographical knowledge, chronological sequence Inhibitors,research,lifescience,medical of experienced events, speech, etc). Another common distinction is between short-term and long-term memory: short-term memory describes a time span of seconds or minutes (sometimes also referred to as working memory), and long-term memory comprises encoding, consolidation, and recall over
or after a long period of time. Memory can
also be classified with regard to content: episodic memory, verbal memory, visual memory, or olfactory memory. Although Inhibitors,research,lifescience,medical there are fewer common syndromic variants of AD, one of its main and early features is an impairment of episodic memory—the capacity to remember past events together with details about the context in which they occurred.2 Episodic memory is an essential cognitive function that supports our ability to form an autobiographical history and helps us to create a concept of the past and the future. The hippocampal network, including Inhibitors,research,lifescience,medical the parahippocampal gyrus, hippocampus, and neocortical areas, play a major role in the process of memory consolidation and retrieval.3 Although its function has not yet fully been understood, the hippocampus seems to be involved in binding features of an event into a mental representation, which is important to form episodic memory. Virtually any neurological, neurodegenerative, toxic, found or traumatic damage to brain structures involved in episodic memory generation, especially the hippocampus, may lead to deficits in episodic memory that may resemble or precede AD;4 especially in the absence of other neurological or neuropsychological symptoms or signs indicative of an alternative cause. Diagnostic approach and diagnostic criteria The diagnostic procedure of memory impairment is firstly based on a comprehensive clinical investigation.