The gel showed a satisfactory result during the assessment of its preliminary stability considering that the formulation remained stable throughout cycles at temperatures of 45 degrees C and 25 degrees C. Parameters obtained
in the validation of the analytical method presented NU7441 satisfactory results for specificity, linearity (r > 0.99), precision (intra-day and inter-day) with relative standard deviation values (R.S.D. %) below the required maximum of 5 %. Accuracy and robustness were consistent with both the objectives of the work and recommendations of the existing laws, providing the reliability of the data obtained during the skin permeation study, evidenced by the gel tendency to promote the permeation of flavonoids, expressed in rutin, through models of synthetic and biological membrane. However, it was observed that the gel had a higher permeability ratio through synthetic membrane, due to greater cumulative mass of rutin quantified after permeation.”
“Tracheal intubation during sevoflurane induction is frequently facilitated with i.v. propofol. We designed a dose-response study to evaluate the intubating conditions, and the incidence and duration of apnea after i.v. propofol in children.
Sixty healthy children were randomly selleckchem assigned to 0, 0.5, 1, 2 or 3 mg.kg(-1) i.v. propofol during sevoflurane/nitrous oxide anesthesia.
Tracheal intubation was performed approximately 30 s after propofol by an anesthesiologist who was blind to the treatment. The anesthesiologist assessed the responses CYT387 purchase to laryngoscopy and intubation using a standardized scale. Incidence
and duration of apnea after propofol as well as heart rate, and systolic blood pressure before and after laryngoscopy were recorded. Data were analyzed using one-way and repeated measures anova, the Jonckheere-Terpstra test, and logistic regression, with P < 0.05 accepted.
The laryngoscopy score after 3 mg.kg(-1) propofol was less than that after 0 mg.kg(-1) (P < 0.01) and 0.5 mg.kg(-1) (P < 0.05). Incidence of apnea after propofol 3 mg.kg(-1), 8/10, was greater than after 0 mg.kg(-1), 3/14 (P < 0.011) and 0.5 mg.kg(-1), 3/12 (P < 0.03). Duration of apnea after 3 mg.kg(-1) was greater than after 0 and 0.5 mg.kg(-1) (P < 0.01). The risk of apnea increased 1.83 fold for each 1 mg.kg(-1) dose increase in propofol (P < 0.01). Mean heart rate and systolic pressure decreased with the main effect, time.
During sevoflurane/nitrous oxide anesthesia, propofol 3 mg.kg(-1) provides superior intubating conditions with an increased incidence of and prolonged apnea compared with 0 and 0.5 mg.kg(-1).”
“Objective: The purpose of this study was to evaluate the usefulness and accuracy of fine needle aspiration cytology (FNAC) in the diagnosis of pediatric parotid tumors.