The model has the following novel features: (i) the complex transmission cycle of RAE has been tractably incorporated into the framework of optimal control problems and (ii) the volume of vermifuge spreading to manage the risk is considered a control variable. With this model, we first obtain the stability conditions for the transmission dynamics under the condition of constant control. Second, we explicitly introduce a control variable of vermifuge spreading into the analysis by considering the associated control costs. In this optimal control problem, we have successfully derived a set of conditions for a bang-bang control and singular control, which are mainly characterized by the prevalence
of infection in voles and foxes and the remaining time of control. The analytical results are demonstrated by numerical analysis and we discuss the AZD1390 order effects of the parameter values on the optimal strategy and the transmission cycle. We find
that when the prevalence Tideglusib nmr of infection in foxes is low and the prevalence of infection in voles is sufficiently high, the optimal strategy is to expend no effort in vermifuge spreading. (C) 2010 Elsevier Ltd. All rights reserved.”
“BACKGROUND: Serum concentrations of adhesion molecules may be connected to the pathogenesis of delayed cerebral infarction (DCI) after aneurysmal subarachnoid hemorrhage (SAH).
OBJECTIVE: To test the hypothesis that levels of adhesion molecules are substantially increased after DCI and decreased
thereafter and that these levels can predict treatment outcomes.
METHODS: Serial circulating markers of adhesion molecules were examined in 21 consecutive SAH patients and 2 risk control subjects. All underwent cerebral angiography and magnetic resonance imaging to confirm the DCI. The timing of magnetic resonance imaging was fixed in the acute phase and before hospital discharge.
RESULTS: Symptomatic DCI developed in 33% of the patients (7 of 21). Statistical analysis of levels of adhesion molecules between patients with and those without DCI revealed that soluble (s) L-selectin, sP-selectin, and sE-selectin concentrations significantly increased after symptomatic DCI (P = .003, .013, and .043, respectively). Only higher sL-selectin aminophylline level on presentation (cutoff value > 636 ng/mL) was significantly associated with poor outcome after 6 months of follow-up.
CONCLUSION: Increased sL-selectin, sP-selectin, and sE-selectin levels imply risks of symptomatic DCI after aneurysmal SAH. The high frequency of symptomatic DCI and higher sL-selectin level on presentation may be associated with worse outcomes.”
“One major problem with the existing algorithm for the prediction of protein structural classes is low accuracies for proteins from alpha/beta and alpha+beta classes. In this study, three novel features were rationally designed to model the differences between proteins from these two classes.