We work on waveguide based sensors which offer a degree of robustness and Wortmannin clinical trial that can be integrated relatively easily into microfluidic structures for lab-on-chip applications [12]. The prompt delivery waveguide structures act as a support platform for immobilizing biochemical recognition elements. We describe a direct-dispense fabrication process to implement the waveguide based sensor arrays. Direct-dispense and direct-write techniques are commonly used for advanced microelectronic packaging, microfabrication, and microelectrodes development [13, 14]. With direct-dispense, Inhibitors,Modulators,Libraries select materials can be precisely deposited with features on the order of several micrometers through a microscale nozzle. A longer term objective is to evaluate the potential of direct-dispense techniques for low-cost printable optical sensor arrays.
Recently, a number of research groups including Inhibitors,Modulators,Libraries Inhibitors,Modulators,Libraries ours have employed the direct-dispense technique to create microfluidic channels and other Inhibitors,Modulators,Libraries microstructures [15, 16]. In literature, we find several fabrication techniques that have been grouped as direct-write techniques which include laser (optical) lithography, ink-jet printing and screen printing [17]. The fabrication technique described here is one example of the several direct-write techniques and involves mechanical robotic deposition to pattern fugitive organic inks on a substrate. Optically transparent epoxy or polymeric materials are then deposited with direct-dispense system using the previously deposited fugitive ink structures as guide or sacrificial layers in a way that is reminiscent of the use of positive photoresists.
Subsequently, the fugitive ink is thermally removed leaving behind micropatterned epoxy or polymeric structures. Inhibitors,Modulators,Libraries This process can be repeated to create complex polymeric microstructures that can be used as high-performance, multi-functional Inhibitors,Modulators,Libraries sensor platforms which can support microfluidics and optical signal collection Inhibitors,Modulators,Libraries and transmission.Sol-gel derived materials have a good potential for creating sensor arrays in combination with direct-dispense techniques. Several reports describe the use of sol-gel-processed xerogels as encapsulation media for various biochemical recognition elements [7, 18, 19].
Xerogels offer a number of advantages, including low temperature processing, optical transparency, relative long time stability, and straightforward doping procedures to encapsulate guest sensing elements.
Xerogel sensor materials have been deposited using pin-printing [7], dip-coating [8], spin-coating Inhibitors,Modulators,Libraries Entinostat [20], and photo-(ultraviolet) patterning [21]. This flexibility makes xerogels attractive to combine with the direct-dispense method. In this paper, we show how modified xerogels can be deposited selectively and integrated fda approved with a patterned polymeric support platform using Cilengitide direct-dispensing. Ru(II) diimine complexes have relatively long lived triplet metal-to-ligand selleck charge transfer states that make them useful for quenchometric sensing.