Chemical library screening responses ngig pathogenic immune

Tion of tobacco and alcohol use, Krankheitsaktivit t team of professionals in search of drugs in order to obtain a remission. Pregnancy outcome is better if patients remain in remission may need during the pregnancy. Drugs for the treatment of IBD still need during the pregnancy safely, with the exception of methotrexate, and thalidomide. To his medication for the treatment of IBD seem to need during the breast-feeding is not safe, with the exception of CsA. Biological agents k Able to 30 Week of pregnancy to continue. Managing the pregnant patient should be multidisciplinary Re inclusion of patients and their partners, family physician, gastroenterologist and to be the midwife. The thiopurines azathioprine and 6-mercaptopurine h Frequently used as anti-cancer and immunosuppressive agents.1, 2 prodrugs that require metabolic chemical library screening conversion to 6 active thioguanine nucleotides via the purine salvage enzyme hypoxanthine phosphoribosyltransferase by, inosine monophosphate dehydrogenase are 5 , and guanosine monophosphate synthetase 5th The predominant catabolic enzymes in the metabolism of thiopurine methyltransferase and xanthine oxidase are include the thiopurine S-known modes of action involving the TGN into DNA or RNA3 lead to apoptosis through the inhibition of replication, DNA repair mechanisms and protein synthesis.4, 5 The agent metabolites 6 methylthioinosine 5-monophosphate inhibits de novo purine synthesis.6 also suppressed 6 thioguanosine triphosphate 5 T-cell-dependent responses ngig pathogenic immune system through a Rac1-dependent ngigen mechanism in patients with inflammatory bowel disease diseases.
Recently, it it was found that 6 thioguanine is also called hypomethylating agent, and this reaction mediated by DNA methyltransferases. 9,10 These epigenetic effect is caused by reduced expression of the histone demethylase lysine-specific suite foreigners Sen of the proteasomal degradation of DNA-methylase DNMT1.11 thiopurine-related side effects are h Frequently explained Rt, ranging from 5% to 40 0.2% of patients with very low TPMT activity t, as a consequence of genetic variation are obtained with a Hten risk of developing severe myelosuppression due to the accumulation of excessive cytotoxic TGN.2, 12,13 dose adjustment buy Pimecrolimus dependent ngig of the activity t or TPMT thiopurine therapy, genetic testing is recommended to treat severe H matotoxizit to avoid t. 14.15 However, independent Ngig of other candidate genes and 16 TPMT, which partly explained Ren, The toxicity Th thiopurinerelated is an essential part of the side effects associated with thiopurine always unpredictable. More than ten years, the monitoring of the major thiopurine metabolites in red blood rperchen been proposed to improve thiopurine therapy, but no clear correlation between TGN levels and inconclusive results in patients with IBD was found many clinical studies2, 17 routine methods for time in place for monitoring the therapeutic nucleotide hydrolysis RBC require before is the quantification of TGN and MMPR by HPLC analysis.18, 19 Based on these methods, however, a differentiation between the individual nucleotides for the respective bases nkt Descr. In addition, specific laboratory conditions for hydrolysis, but also the method of the work-up other differ between the various clinical laboratories, contributing to the differences between gene test results.