However, the total energy difference gives much worse binding energies when compared to experiment due to the self-interaction error in the local density approximation. We conclude that one must go beyond the usual approximations of the density functional theory in order to predict accurately the binding energies of these shallow impurities. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3153981]“
“This study aims to identify key miRNAs in circulation, which
predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression learn more levels to beta-cell function and glycaemic control. Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n = 275 and 129, resp.) and one control group (n = 151). We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks. Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: -0.12, P = 0.0037), and positively associated with glycaemic control
(HbA1c) AZD2014 (est.: 0.11, P = 0.0035) 3 months after onset. In conclusion this study demonstrates that miR-25 might be a “”tissue-specific”" miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets.”
“Polybrominated diphenyl ethers (PBDEs) and polychlorinated
biphenyls (PCBs) are ubiquitous environmental pollutants. Exposure to these chemicals has been associated with developmental neurotoxicity, endocrine dysfunction, and reproductive disorders. Humans and wildlife are generally Selleck MAPK Inhibitor Library exposed to a mixture of these environmental pollutants, highlighting the need to evaluate the potential effects of combined exposures. In this study, we investigated the cytotoxic effects of the combined exposure to two PBDEs and two PCBs in a human neuronal cell line. 2,2 ‘,4,4 ‘-Tetrabromodiphenyl ether, 2,2 ‘,4,4 ‘,5-pentabromodiphenyl ether, PCB-126 (3,3 ‘,4,4 ‘,5-pentachlorobiphenyl; a dioxin-like PCB), and PCB-153 (2,2 ‘,4,4 ‘,5,5 ‘-hexachlorobiphenyl; a non-dioxin-like PCB) were chosen, because their concentrations are among the highest in human tissues and the environment. The results suggest that the nature of interactions is related to the PCB structure. Mixtures of PCB-153 and both PBDEs had a prevalently synergistic effect.